Defending U.S. Open champion Novak Djokovic knocked out in shock defeat

Djokovic bowed out with a 6-4, 6-4, 2-6, 6-4 loss to 28th-seeded Alexei Popyrin of Australia, another shocking result at Flushing Meadows one night after Carlos Alcaraz exited.

(Image credit: Julia Nikhinson)